Fluticasone propionate ointment

Fluticasone propionate ointment

What is Fluticasone propionate ointment?

  • Fluticasone propionate ointment is a synthetic pharmaceutical corticosteroid ointment (Glucocorticoid), a steroid hormone derivative.
  • The ointment is available under generic name Fluticasone propionate and brand names “Cutivate ointment” and marketed by Pharma Derm, a division of Nycomed Us Inc./ Fougera Pharmaceuticals Inc.
  • The Fluticasone propionate is a topical steroid used to treat inflammatory and pruritic /itching symptoms caused by various skin problems such as allergic reaction, dermatoses, eczema and psoriasis.
  • The Fluticasone propionate ointment contains the active ingredient of Fluticasone propionate (005%).
  • The drug has received its official approval from US Food and Drug Administration (FDA) in October 1994 to treat dermatoses, psoriasis and other allergic conditions.

Fluticasone propionate ointment

Pharmacophore structure: Information about the chemical structure of the Fluticasone propionate.

  • The Fluticasone propionate is a synthetic fluorinated steroid compound that belongs to the class of organic compounds known as steroid esters i.e steroid moiety with a carboxylic acid ester group.
  • The compound is chemically known as S-(fluoromethyl)6α,9-difluoro-11β-17-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioate, 17-propionate.
  • The compound has molecular formula C25H31F3O5S and the molecular weight of 500.571 Da.

How to store and use the medicine?

  • Fluticasone propionate is available in cream/lotion/ointment form for topical use.
  • The concentration of Fluticasone propionate is 0.005 % and supplied in 15g/30g/60g tube.
  • The storage temperature of Fluticasone propionate is 2° and 30°C (36° and 86°F).
  • The ointment is applied as a thin film and rubbed gently to the affected areas of skin twice a day.
  • It is usually prescribed not to use ointment with occlusive dressings i.e. should not be bandaged or otherwise covered or wrapped.
  • The medication should be used for external use and under guidance of a physician. Avoid eye contact and should not be used on the underarms, or groin areas and face, unless otherwise directed by the physician.
  • Do not use the ointment without prescription during pregnancy. Inform your doctor if you are pregnant or plan to become pregnant. Tell your doctor if you are breastfeeding.

How the fluticasone propionate ointment works (mode of action)?

  • It chemically mimic to corticosteroid hormones which is produced by the adrenal glands.
  • The drug is a highly selective agonist at the glucocorticoid receptor and therefore acts as a potent anti-inflammatory medication.
  • Fluticasone propionate has shown inhibitory effect on a very wide of cell types such as neutrophils, macrophages, mast cells, lymphocytes and eosinophils.
  • Following use, drug crosses the cell membrane and binds with high affinity to the glucocorticoid receptors thus altering transcription, protein synthesis and cell signaling.
  • This results in inhibition of synthesis of mediators/precursors of inflammation i.e. cytokines, histamine, leukotrienes and eicosanoids.
  • Following administration the drug is rapidly metabolized in liver by cytochrome P450 3A4.

Suggested literature:

  • Fluticasone propionate – Wikipedia. wikipedia.org/wiki/Fluticasone_propionate
  • DrugBank: Fluticasone Propionate (DB00588). drugbank.ca/drugs/DB00588
  • Fluticasone Propionate | C25H31F3O5S | ChemSpider. chemspider.com/Chemical-Structure.392059.html
  • The anti-inflammatory profile of fluticasone propionate. ncbi.nlm.nih.gov/pubmed/7604948.
  • Fluticasone propionate ointment. Medine.net.http://www.medicinenet.com/fluticasone_propionate-topical/article.html
  • Comparison of fluticasone propionate ointment, 0.005%, and betamethasone-17,21-dipropionate ointment, 0.05%, in the treatment of psoriasis. http://www.ncbi.nlm.nih.gov/pubmed/8646866
  • A comparison of fluticasone propionate ointment, 0.005%, and hydrocortisone-17-butyrate ointment, 0.1%, in the treatment of psoriasis. http://www.ncbi.nlm.nih.gov/pubmed/8646868

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